What signs indicate a patient may be in pain?

Facial grimacing, restlessness, and changes in vital signs are significant indicators that a patient may be experiencing pain. Facial grimacing often accompanies discomfort, as individuals may involuntarily express their distress through their facial expressions. Restlessness can signal an inability to find a comfortable position due to pain. Additionally, vital signs such as increased heart rate or elevated blood pressure can reflect the body's physiological response to pain, indicating that the patient may be in distress. All these signs combined suggest a heightened level of discomfort that warrants further assessment and intervention. The other options present characteristics typically associated with comfort and well-being, which do not indicate the presence of pain.